Neuronal activity impacts how newborn neurons integrate into functional synaptic circuits. This activity dependent sculpting of synaptic circuitry during development and at a slower pace in the adult, represents a type of synaptic plasticity whereby neuronal connectivity slowly changes over time. We focus on performing stable, precise, and well characterized genetic manipulations. Systems to gain molecular insight into the physiologically relevant phenotypes we uncover.

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Tuesday, October 2, 2012. In Tibetan Buddhism, the prostration begins, standing, with hands overhead in prayer. First, touching the hands to the crown of the head, next the throat, and moving to the heart. Then, lowering the body down to the knees. And finally, stretching completely face down on the ground. Moving the hands again into overhead prayer. It is an action of surrender. My mind shoots in twenty directions. It occurs to me just how.

It just fell out of my mind one morning. Lets be clear about this. They would and have pressed. The button to annihilate cities, millions of peoples. more than just nasty people taxing bedrooms taking food from the poor discarding the disabled. or just examples of what they might do if pushed to keep us in our place. Is it them or us.